Shotgun metagenomics data from faecal samples of 47 patients with mild cognitive impairment: Insights from the memoir study

This Data Note describes the MEMOIR dataset, consisting of shotgun metagenomics data from faecal samples of 47 individuals over the age of 65 diagnosed with mild cognitive impairment (MCI). The dataset was generated to investigate the relationship between gut microbiota functionality and cognitive impairment through the gut-brain-microbiota axis. The dataset includes sequencing data that can be used to explore gut microbiota gene profiles linked to MCI. The dataset was generated using high-throughput shotgun metagenomics technology to identify microbial genes and their potential involvement in cognitive health. This allows for functional interrogation of the gut microbial community and its impact on MCI progression, providing a rich resource for future research. The dataset supports analyses aimed at understanding how dietary interventions (Mediterranean diet and WHO diet) and probiotic treatments influence MCI progression, as well as the potential sex-based differences in response to these interventions. The MEMOIR dataset adheres to the FAIR principles and is intended to facilitate reproducibility and data reuse in studies exploring the gut microbiota’s role in cognitive decline. No conclusions or analyses are presented in this note, but the dataset offers potential for novel insights into personalised treatment strategies for MCI in ageing populations. Future publications from the MEMOIR project will explore the results from these analyses in detail, contributing to a better understanding of the role of gut microbiota in cognitive decline and identifying potential microbial targets for intervention.

ClinicalTrials.gov, identifier NCT05029765, registration date of 2021-09-01. For further details, please refer to: https://clinicaltrials.gov/study/NCT05029765?term=NCT05029765&rank=1

This Data Note presents the MEMOIR dataset, which contains data from faecal samples of 47 people over the age of 65 who have mild cognitive impairment (MCI). MCI is a disorder that impacts memory and cognitive abilities and has the potential to progress to dementia. The data collected aims to investigate the relationship between gut bacteria (gut microbiota) and their influence on cognitive health, mediated by the gut-brain-microbiota axis. Through the application of cutting-edge DNA sequencing techniques, the dataset offers comprehensive insights into the genetic profiles of gut bacteria that may contribute to cognitive decline. This information is crucial for researchers examining the role of gut microbiota in conditions such as MCI. Additionally, the dataset facilitates exploration of the effects of dietary patterns, specifically the Mediterranean diet and the World Health Organization (WHO) recommended diet, along with probiotic interventions, on MCI, including potential gender-based differences in treatment response.

The MEMOIR dataset follows high standards to make sure it is easy to use and share, and no conclusions are drawn from the data in this report. However, this data will support future studies that aim to find new ways to prevent or treat MCI by targeting the gut microbiota. Upcoming publications from the MEMOIR project will explore these findings in more detail, helping us better understand how the gut bacteria might play a role in cognitive decline and how we can develop treatments to slow or reverse it.