European & Developing Countries Clinical Trials Partnership (EDCTP)

About

Browse

EDCTP is a public–public partnership between 15 European and 28 African countries, supported by the European Union.

EDCTP’s vision is to reduce the individual, social and economic burden of poverty-related infectious diseases affecting sub-Saharan Africa.

EDCTP’s mission is to accelerate the development of new or improved medicinal products for the identification, treatment and prevention of infectious diseases, including emerging and re-emerging diseases, through pre- and post-registration clinical studies, with emphasis on phase II and III clinical trials. Our approach integrates conduct of research with development of African clinical research capacity and networking.

Research Article

Awaiting peer review

Health services intervention integrating HTN and HIV care improves long-term blood pressure control among people living with HIV in Uganda

Authors: Emmy Okello, Mucunguzi Atukunda, Laura B. Balzer, Elizabeth Arinitwe, Brian Twinamtsiko, Michael Ayebare, Winstone Tindimwebwa, Joan Nangendo, James Kayima, Gerald Mutungi, Saidi Kapiga, Edwin D. Charlebois, Moses R. Kamya, Heiner Grosskurth, Jane Kabami

Funders: European & Developing Countries Clinical Trials Partnership (EDCTP)

Peer reviewers: No information provided

Published: October 12, 2026
Research Article

Peer review process completed

Navigating ethical research during crisis: Facilitators and barriers to research conduct in Uganda amid the public health emergencies (COVID-19)

Authors: Christopher Ddamulira, Hellen Opolot, Beth Mutumba, Dorcas Lamunu, Steven Ssebale, Irene Semakula, Jacob Komakech, Bernard Kikaire, Helen Byomire Ndagijje, Vivian Nchanchou Mbanya, Rosemarie De La Cruz Bernabe

Funders: Horizon Europe, European & Developing Countries Clinical Trials Partnership (EDCTP)

Peer reviewers: Gerry A. Quinn

Published: July 8, 2026
Research Article
Revised
Peer review process completed

Preparedness for diphtheria epidemic among healthcare workers in Kano State, Nigeria

Authors: Ayodele Arinola Feyisara, Noah David, Etim Utibe Efre, Kevin Dofwah Nuhu, Azibadighi Walter, Olufunmilayo Ibitola Fawole, Adeniyi Francis Fagbamigbe, Segun Bello, Onoja Matthew Akpa

Funders: European & Developing Countries Clinical Trials Partnership (EDCTP)

Peer reviewers: David Broderick, Thang Nguyen, Ukamaka Okafor

Published: September 15, 2026
Case Study
Revised
Peer review process completed

The ASCEND Project (2020-2023): Strengthening clinical trial ethics review and pharmacovigilance capacity in Tanzania mainland and Zanzibar

Authors: Ndekya Oriyo, Nyanda Ntinginya, Damas Matiko, Blandina Mmbaga, Wilber Sabiiti, Emmanuel Masunga, Ruby Mcharo, Ame Masemo, Sunzy Chambiri, Yonah Mwalwisi, Bora Lichanda, Mayassa Ally, Burhani Simai, Eliangiringa Kaale, Kissa Mwamwitwa, Adam Fimbo

Funders: European & Developing Countries Clinical Trials Partnership (EDCTP)

Peer reviewers: Basile Chrétien, Gabriela Lenarczyk

Published: October 6, 2026
Research Article

Peer review process completed

Evaluating implementation and participants’ engagement with digital adherence tools (DAT) to improve antiretroviral adherence among children and adolescents living with HIV in Tanzania. A mixed method study

Authors: Iraseni Ufoo Swai, Takondwa Msosa, Doris Wopereis, Kennedy Ngowi, Benson Mtesha, Rehema Maro, Lyidia V Masika, Naomi Emmanuel, Alan Mtenga, Perry Cyril Msoka, Blandina T Mmbaga, Marriott Nliwasa, Tobias F Rinke de Wit, Rob Aarnoutse**, Marion Sumari-de Boer**

Funders: European & Developing Countries Clinical Trials Partnership (EDCTP)

Peer reviewers: Tariq Jagnarine

Published: January 2, 2026
Research Article

Peer review process completed

Molecular profiling of human malaria parasites among individuals suspected for malaria in three geo-ecological facets of malaria transmission in Cameroon.

Authors: Innocent Mbulli Ali, Keming Eva Mai, Marcel Nyuylam Moyeh, Indira Lontsie Saha, Darlin Bean Kaunda Nguene, Valery Pacome Tchuenkam, Giresse Lemogo, Mariama Mbouh, Arsene Dombou, Miriam Ngum Niba, Onesime Djerassem, Colette Noudou Nathan Belinga, Guillaume Ndjiofack Nguefack, Richard Folefock Ajua, Gustave Simo, Michel Noubom, Albert Zeh Meka, Leke Rose

Funders: European & Developing Countries Clinical Trials Partnership (EDCTP)

Peer reviewers: Cynthia Odhiambo

Published: January 2, 2026
Research Article
Revised
Peer review process completed

Caregivers’ perceptions of childhood pneumonia in Western Kenya: a theory of practice perspective

Authors: Sarah Hawi Ngere, Charles Omondi Olang'o, Patience Kiyuka, Eucabeth Awuonda, Caleb Kimutai Sagam, Benard Ochieng, Stephen Okumu Ombere, Erick Nyambedha

Funders: European & Developing Countries Clinical Trials Partnership (EDCTP)

Peer reviewers: Prashant Kulkarni

Published: February 11, 2026
Research Article

Peer review process completed

Knowledge, attitudes and perceptions on the Covid-19 response in rural and urban areas of the Democratic Republic of the Congo

Authors: Mireille Ngale Amba, Daniel Mukadi-Bamuleka, Joël Kiniati Fumwankau, Aline Engo-Biongo, Jean-Paul Divengi Nzambi, Therèse Mpiempie Ngamasata, Tarcisse Kilara kapene, Nsengi Ntamabyaliro, Samuel Mapunza Ma-Miezi, Matthew Bates, John Tembo, Luchuo Engelbert Bain, Gauthier Mesia Kahunu, Gaston Tona Lutete

Funders: European & Developing Countries Clinical Trials Partnership (EDCTP)

Peer reviewers: Francis Ejeh

Published: July 30, 2025
Research Article
Revised
Peer review process completed

Immunomodulatory effect of Moringa oleifera and Phyllanthus niruri extracts on anti-HBV cytokine production by human peripheral blood mononuclear cells

Authors: Bright Asare, Philip Selorm Segbefia, Rawdat Awuku-Larbi, Diana Asema Asandem, Theophilus Brenko, Lutterodt Bentum-Ennin, Frank Osei, Doreen Teye-Adjei, Georgina Agyekum, Linda Akuffo, Bethel Kwansa-Bentum, Kwadwo Asamoah Kusi

Funders: European & Developing Countries Clinical Trials Partnership (EDCTP)

Peer reviewers: Edward Maina, Michael Adinortey, Sujogya Panda

Published: December 4, 2025
Study Protocol
Revised
Peer review process completed

Investigating the dynamics of Plasmodium falciparum gametocyte carriage in expectant women under intermittent preventive treatment with sulfadoxine-pyrimethamine in Kilifi, study protocol

Authors: Patience Kerubo Kiyuka, Mark Muricho, Nelson Ouma, Charles Muiruri, Amek Nyaguara, Martin Rono, Isabella Oyier, Mainga Hamaluba

Funders: European & Developing Countries Clinical Trials Partnership (EDCTP)

Peer reviewers: Adebanjo Adegbola, Liusheng Huang, Roland Funwei

Published: April 11, 2025
Research Article

Peer review process completed

Caregivers’ self-medication practices for perceived febrile illnesses among under-five children in central river region, the Gambia

Authors: Haita Ndimballan, Ayo Adebowale, Ikeoluwapo Ajayi

Funders: Horizon 2020, European & Developing Countries Clinical Trials Partnership (EDCTP)

Peer reviewers: Anas Alhur, Arifa Saif

Published: January 29, 2025
Study Protocol

Peer review process completed

The STROGHAT study protocol: An intervention study to evaluate safety, effectiveness and feasibility of treating gambiense HAT seropositive subjects with acoziborole.

Authors: Elena Nicco, Veerle Lejon, Erick Mwamba Miaka, Dieudonné Mumba, Alain Mpanya, Charles Kambo, Digas Ngolo, Wilfried Mutombo, Stéphane Hugonnet, Sandra Rembry, Craig Tipple, Raquel Inocencio Da Luz, Rian Snijders, Catiane Vander Kelen, Stijn Rogé, Nick Van Reet, Antoine Tarral, Paul Verlé, Epco Hasker

Funders: Horizon Europe, European & Developing Countries Clinical Trials Partnership (EDCTP)

Peer reviewers: Ifedayo Victor Ogungbe, Michael Barrett

Published: January 24, 2025
Research Article

Peer review process completed

Targeting Plasmodium falciparum chondroitin sulfate a ligand: A highly conserved malaria antigen with potential for pregnancy-associated malaria vaccine development

Authors: Alex K. Rotich, Kevin Mbogo, Paulus Adamba, Eizo Takashima, Jesse Gitaka, Bernard N. Kanoi

Funders: Horizon Europe, European & Developing Countries Clinical Trials Partnership (EDCTP)

Peer reviewers: Jeroen Bok, Prasun Feltwell

Published: January 14, 2025
Research Article

Peer review process completed

A biobank resource for placental malaria and placental health research

Authors: Melvin Mbalitsi, Mercy Singoei, Samuel Chenge, Harrison M. Ngure, Paul O. Angienda, Moses Madadi Obimbo, Bernard N. Kanoi, Jesse Gitaka, Francis M. Kobia

Funders: Horizon Europe, European & Developing Countries Clinical Trials Partnership (EDCTP)

Peer reviewers: Julie Moore, Stephen Rogerson

Published: December 24, 2024
Review

Peer review process completed

The pregnancy-associated secretome in malaria pathogenesis and immunity during gestation

Authors: Lucy Mwai, Paulus Adamba, Benjamin Mordmüller, Manu Vatish, Yoel Sadovsky, Jesse Gitaka, Francis M. Kobia, Bernard N. Kanoi

Funders: Horizon Europe, European & Developing Countries Clinical Trials Partnership (EDCTP)

Peer reviewers: Andrew Teo, Eliana María Arango Flórez, Jeremiah Laktabai, Kemi AMODU

Published: October 17, 2024
Research Article

Peer review process completed

Ex-vivo evaluation of Plasmodium falciparum-induced cytokine expression in chronic hepatitis B virus-infected and uninfected individuals

Authors: Selorm Philip Segbefia, Diana Asema Asandem, Bright Asare, Rawdat Awuku-Larbi, William van der Puije, Eric Kyei-Baafour, Frank Osei, Doreen Teye-Adjei, Georgina Agyekum, Oscar Darko, Seth Agyemang, Lutterodt Bentum-Ennin, Kofi J. H. Bonney, Samuel Asamoah Sakyi, Linda Eva Amoah, Kwadwo Asamoah Kusi

Funders: Horizon Europe, European & Developing Countries Clinical Trials Partnership (EDCTP)

Peer reviewers: Antonio Bertoletti

Published: October 15, 2024
Research Article
Revised
Peer review process completed

Post-trial access practices in conducted clinical trials for Malaria, Tuberculosis, and Neglected Tropical Diseases (NTDs) across Sub-Saharan African countries: A quantitative study

Authors: Yemisrach Seralegne, Cynthia Khamala Wangamati, Rosemarie de la Cruz Bernabe, Ibrahim Mdala, Martha Zewdie, Hawult Taye Adane

Funders: Horizon 2020, European & Developing Countries Clinical Trials Partnership (EDCTP)

Peer reviewers: George Ayodo, Irene Kyomuhangi, Promise Okereke, Richard Idro

Published: November 11, 2025
Research Article

Peer review process completed

Financial, Supplies, and Human Resource Preparedness in Management of Covid-19 Pandemic Among Dental Facilities in Nairobi County Kenya

Authors: Hazel Chematia, Simon Karanja, Elizabeth Kiilu

Funders: European & Developing Countries Clinical Trials Partnership (EDCTP)

Peer reviewers: Katarzyna Gurzawska-Comis

Published: September 26, 2024
Research Article

Peer review process completed

Low levels of hypertension screening in HIV care clinics in rural Uganda: A mixed methods study

Authors: Mucunguzi Atukunda, Edwin D. Charlebois, Brian Twinamatsiko, Ambrose Byamukama, Andrew Mutabazi, Cecilia Akatukwasa, Michael Ayebare, Winston Tindimwebwa, Alan Asiimwe, Geoff Lavoy, Elizabeth Arinitwe, Joan Nangendo, Justus Tumusiime, Laura B. Balzer, Emmy Okello, Gerald Mutungi, Heiner Grosskurth, Moses R. Kamya, Jane Kabami

Funders: Horizon 2020, European & Developing Countries Clinical Trials Partnership (EDCTP)

Peer reviewers: Veronica Tonwe

Published: September 9, 2024
Research Article
Revised
Peer review process completed

A Hospital-Based Survey Assessing Facility-Level Factors Contributing to Late-Stage Cervical Cancer Diagnosis: A Mixed-Methods Approach.

Authors: Marthaclaire Zammit, Jackline Nyaberi, Susan Mambo, Careena Otieno

Funders: European & Developing Countries Clinical Trials Partnership (EDCTP)

Peer reviewers: Bernardo Vega, Leon Snyman, diane HARPER, rogers Kajabwangu

Published: February 6, 2025
Research Article
Revised
Peer review process completed

The proportion and determinants of appropriate health seeking behavior for febrile illness among caregivers of children under-five years in Butula sub-county, Busia county, Kenya

Authors: Jean L. Kananura, Betsy C.Rono, Kamija S.Phiri

Funders: European & Developing Countries Clinical Trials Partnership (EDCTP)

Peer reviewers: CHIJIOKE EZENYEAKU, Oluseye Okunola, Prashant Kulkarni

Published: December 12, 2024
Research Article

Awaiting peer review

Prevalence and individual level enablers and barriers for COVID-19 vaccine uptake among adult tuberculosis patients attending selected clinics in Nairobi County, Kenya

Authors: Boru Waqo, George Makalliwa, Caroline Musita

Funders: European & Developing Countries Clinical Trials Partnership (EDCTP)

Peer reviewers: No information provided

Published: July 9, 2024
Research Article
Revised
Peer review process completed

Utilization of sexual and reproductive health services among young people living with HIV and attending selected HIV clinics in selected sub-counties of Nairobi, Kenya

Authors: Nomsa Phiri, Susan Mambo, Careena Otieno Odawa

Funders: European & Developing Countries Clinical Trials Partnership (EDCTP)

Peer reviewers: Melkamu Merid Mengesha, Naomi Wekwete, Sylvia Ayieko

Published: July 25, 2025
Research Article
Revised
Peer review process completed

Risky sexual behaviours and utilization of HIV testing services among the adolescent girls and young women aged between 15-24 years in Kibra Sub County, Nairobi County, Kenya

Authors: Onesmus Muti Mutie, Kenneth Ngure, Aggrey Gisiora Mokaya

Funders: European & Developing Countries Clinical Trials Partnership (EDCTP)

Peer reviewers: Alfred Musekiwa, Elizabeth Kiilu

Published: January 31, 2025
Research Article
Revised
Peer review process completed

Utilization and associated determinants of multi-sectoral approach in zoonotic disease surveillance among animal and human healthcare workers in Nakuru County, Kenya

Authors: Levi Cheptoyek, Gideon Kikuvi, John Gachohi

Funders: European & Developing Countries Clinical Trials Partnership (EDCTP)

Peer reviewers: Budi Utomo, Jolly Musoke, Nick Wheelhouse

Published: September 2, 2024